Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Therefore, PI3K/Akt pathway may play an important role in the activation of Nrf2 and COPD inflammation.
|
30827233 |
2019 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrated that expression of the Nrf2-regulated antioxidant enzymes was decreased in a patient with chronic obstructive pulmonary disease associated with PH.
|
23590302 |
2013 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, the Nrf2 mRNA level was decreased in laser capture microdissection-retrieved macrophages obtained from subjects with COPD (n = 10) compared with control subjects (n = 10) (P = 0.001).
|
18566336 |
2008 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Under disease conditions, PSTC engaged its target, inducing the expression of Nrf2-regulated genes in human bronchial epithelial cells derived from patients with chronic obstructive pulmonary disease, as well as in the lungs of cigarette smoke-exposed mice.
|
28790194 |
2017 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Bronchial epithelium is the most responsive tissue for transcriptional activation of Nrf2 target genes in active smokers compared to former-smokers with COPD that correlated with oxidative stress and inflammatory markers.
|
31429757 |
2019 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Plasma Nrf2 and CRP levels significantly increased in a stepwise manner with an increase in inflammatory status (control vs. COPD-stable vs. COPD-exacerbation) (p = 0.002, p < 0.001).
|
29529843 |
2018 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Agonists of the cytoprotective transcription factor Nrf2 (sulforaphane and compound 7) reverse defects in phagocytosis of S. pneumoniae and nontypeable Haemophilus influenzae by COPD AMs.
|
29547002 |
2018 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We verified using the preclinical COPD-emphysema murine model that chronic CS (Ch-CS)-induced inflammation (interleukin [IL]-6/IL-1β levels), aggresome formation (perinuclear coexpression/colocalization of ubiquitinated proteins [Ub] and p62 [impaired autophagy marker], and CFTR), oxidative/nitrosative stress (p-Nrf2, inducible nitric oxide synthase [iNOS], and 3-nitrotyrosine expression), apoptosis (caspase-3/7 activity), and alveolar airspace enlargement (Lm) are significantly (p < 0.05) alleviated by augmenting airway GSNO levels.
|
28006950 |
2017 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the Nrf2 mRNA level was decreased in laser capture microdissection-retrieved macrophages obtained from subjects with COPD (n = 10) compared with control subjects (n = 10) (P = 0.001).
|
18566336 |
2008 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, monocyte-derived macrophages obtained from healthy volunteers (non-smokers and smokers) and COPD patients showed a significant correlation between HDAC2 expression and Nrf2 expression (r=0.92, p<0.0001).
|
21320471 |
2011 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Nrf2 expression was lower in COPD patients than in control subjects.
|
26861788 |
2016 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The HO-1, NF-κB and 8-OHdG were found highly expressed in COPD rat lung, particularly at the higher PM<sub>2.5</sub> dose of cold stress groups, while Nrf2 was found declined.
|
29793105 |
2018 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Based on these findings, BML-111 may prevent NLRP3 inflammasome activation and inhibit ROS production via upregulation of Nrf-2, thereby exerting an anti-inflammatory effect on COPD model mice.
|
30102962 |
2018 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Recuperating lung decoction attenuates inflammation and oxidation in cigarette smoke-induced COPD in rats via activation of ERK and Nrf2 pathways.
|
28749079 |
2017 |
Chronic Obstructive Airway Disease
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The transcription factor NRF2 is a critical player in the battle against oxidative stress and its function is impaired in COPD.
|
27832175 |
2016 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nuclear erythroid-related factor 2 (Nrf2) regulates antioxidant defensive mechanism in COPD.
|
28347799 |
2017 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Nrf2-antioxidant pathway has been shown to be important in the protection against various lung injuries including acute lung injury/acute respiratory distress syndrome and bronchopulmonary dysplasia, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, asthma, and allergy and was widely examined for new therapeutic targets.
|
27864288 |
2017 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
This data-mining review supports the notion that Nrf2-regulated anti-oxidant genes play a central role in protection against tobacco smoke toxic effects and may be amenable to use as COPD risk biomarkers.
|
20594977 |
2010 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therapy with astaxanthin directed toward activating the Nrf2 pathway has the potential to be a novel preventive and therapeutic strategy for COPD.
|
31795292 |
2019 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, Nrf2 mediates the protective effects of both Wnt3a/β-catenin and AMPK on lung inflammatory responses during the development of COPD/emphysema.
|
29659176 |
2018 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore we studied the relation between NFE2L2 and all-cause, cardiovascular, and COPD mortality and its associations with triglyceride and cholesterol levels.
|
24790085 |
2014 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Because Nrf2 failure significantly contributes to the development of COPD, our findings suggest that the possibility to prevent Nrf2 reduction may open a new scenario in helping to prevent the oxidative stress-associated lung function decline.
|
27555763 |
2016 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conclude that NRF2 is a novel drug target for reversing corticosteroid resistance in COPD and other corticosteroid-resistant inflammatory diseases.
|
22005302 |
2011 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, ILG protected against CS-induced COPD by inhibiting inflammatory and oxidative stress via the regulation of the Nrf2 and NF-κB signaling pathways.
|
30294270 |
2018 |
Chronic Obstructive Airway Disease
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate the importance of Nrf2 and its downstream target MARCO in improving antibacterial defenses and provide a rationale for targeting this pathway, via pharmacological agents such as sulforaphane, to prevent exacerbations of COPD caused by bacterial infection.
|
21490276 |
2011 |